MyBioSource.com's Mst3b (Mammalian Ste20-like Kinase) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
Mammalian Ste20-like kinases, including Mst1-4, belong to the germinal center kinase (GCK) family. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast Ste20 kinase and other p21-activated kinases (1). The carboxy-terminal region of Mst1 and Mst2 contains a dimerization and an inhibitory domain, while the carboxy-terminal region of Mst3 and Mst4 are not well characterized (1-3). Dimerization and phosphorylation at the activation loop regulates translocation of Mst1 from the cytosol to the nucleus (3). Growing evidence indicates that Mst1 and Mst2 are activated by apoptotic signals as well as other stress conditions (4-6). The full activation of Mst1 requires both phosphorylation and caspase-mediated cleavage (4). Activated Mst kinases may rely on p38 MAPK and JNK pathways to amplify apoptotic signals (5). Inhibitory phosphorylation is also reported. Phosphorylation at serine 327 of Mst1, which